ParkinsonFranceV1, Main, Exploration, bibRecord, 001D16

Segmental progression of early untreated Parkinson's disease: a novel approach to clinical rating

Identifieur interne : 001D16 ( Main/Exploration ); précédent : 001D15; suivant : 001D17

Segmental progression of early untreated Parkinson's disease: a novel approach to clinical rating

Auteurs : W. M. M. Schüpbach [France, Suisse] ; J.-C. Corvol [France] ; V. Czernecki [France] ; M. B. Djebara [France] ; J.-L. Golmard [France] ; Yves Agid [France] ; A. Hartmann [France]

Source :

Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2010.

RBID : Pascal:10-0032960

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Voie abord.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Surgical approach.

Abstract

Objective: To assess the ability of potentially neuroprotective compounds to slow the progression of Parkinson's disease (PD), sensitive rating scales are needed to detect clinically meaningful effects. The topographical progression of motor signs in early untreated PD was evaluated to complement current clinical ratings and enhance the sensitivity to detect disease progression. Methods: 12 patients referred for diagnostic evaluation of untreated de novo PD underwent detailed clinical assessment of motor parkinsonian signs at baseline and after 6 and 12 months of follow-up using the Unified Parkinson's Disease Rating Scale, motor part (UPDRS-III), and a newly developed approach of detailed segmental rating taking into account the localisation of motor signs in all of the major joints and muscle groups in the body. The progression of PD, as measured with the UPDRS-III, was compared with the segmental ratings. Results: UPDRS-III scores and segmental ratings for rigidity and rest and postural tremor, but not bradykinesia, progressed significantly during the observation period. Progression of normalised segmental ratings for rigidity and tremor was significantly larger than the UPDRS-III ratings over 1 year. The segmental ratings for rigidity and tremor as well as their combination with the UPDRS-III bradykinesia rating were more sensitive a measure for progression of PD than the UPDRS-III. Conclusions: Taking into account the segmental evolution of parkinsonian signs may be a useful adjunct to UPDRS-III evaluations to measure clinical disease progression of PD. If validated in subsequent larger cohorts, this may be useful in trials of neuroprotective agents.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000624
to stream PascalFrancis, to step Curation: 000D33
to stream PascalFrancis, to step Checkpoint: 000450
to stream Main, to step Merge: 001E37
to stream Main, to step Curation: 001D16

Le document en format XML

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<s2>Paris</s2>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>AP-HP, Pitié-Salpêtrière Group, Fédération de Neurologie</s1>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>INSERM UMR 610, Functional Neuroanatomy of Normal and Pathological Behaviour</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Djebara, M B" sort="Djebara, M B" uniqKey="Djebara M" first="M. B." last="Djebara">M. B. Djebara</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre d'Investigation Clinique, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, UMR 679, Neurology and Experimental Therapeutics</s1>
<s2>Paris</s2>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>AP-HP, Pitié-Salpêtrière Group, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University Pierre et Marie Curie, Faculté de Médecine</s1>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
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<author><name sortKey="Golmard, J L" sort="Golmard, J L" uniqKey="Golmard J" first="J.-L." last="Golmard">J.-L. Golmard</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>AP-HP, Pitié-Salpêtrière Group, Biostatistics Unit</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre d'Investigation Clinique, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, UMR 679, Neurology and Experimental Therapeutics</s1>
<s2>Paris</s2>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>AP-HP, Pitié-Salpêtrière Group, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University Pierre et Marie Curie, Faculté de Médecine</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A." last="Hartmann">A. Hartmann</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Centre d'Investigation Clinique, Fédération des Maladies du Système Nerveux</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM, UMR 679, Neurology and Experimental Therapeutics</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>AP-HP, Pitié-Salpêtrière Group, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University Pierre et Marie Curie, Faculté de Médecine</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title>
<title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title>
<idno type="ISSN">0022-3050</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title>
<title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title>
<idno type="ISSN">0022-3050</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Surgical approach</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Voie abord</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To assess the ability of potentially neuroprotective compounds to slow the progression of Parkinson's disease (PD), sensitive rating scales are needed to detect clinically meaningful effects. The topographical progression of motor signs in early untreated PD was evaluated to complement current clinical ratings and enhance the sensitivity to detect disease progression. Methods: 12 patients referred for diagnostic evaluation of untreated de novo PD underwent detailed clinical assessment of motor parkinsonian signs at baseline and after 6 and 12 months of follow-up using the Unified Parkinson's Disease Rating Scale, motor part (UPDRS-III), and a newly developed approach of detailed segmental rating taking into account the localisation of motor signs in all of the major joints and muscle groups in the body. The progression of PD, as measured with the UPDRS-III, was compared with the segmental ratings. Results: UPDRS-III scores and segmental ratings for rigidity and rest and postural tremor, but not bradykinesia, progressed significantly during the observation period. Progression of normalised segmental ratings for rigidity and tremor was significantly larger than the UPDRS-III ratings over 1 year. The segmental ratings for rigidity and tremor as well as their combination with the UPDRS-III bradykinesia rating were more sensitive a measure for progression of PD than the UPDRS-III. Conclusions: Taking into account the segmental evolution of parkinsonian signs may be a useful adjunct to UPDRS-III evaluations to measure clinical disease progression of PD. If validated in subsequent larger cohorts, this may be useful in trials of neuroprotective agents.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Schupbach, W M M" sort="Schupbach, W M M" uniqKey="Schupbach W" first="W. M. M." last="Schüpbach">W. M. M. Schüpbach</name>
</region>
<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J.-C." last="Corvol">J.-C. Corvol</name>
<name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J.-C." last="Corvol">J.-C. Corvol</name>
<name sortKey="Corvol, J C" sort="Corvol, J C" uniqKey="Corvol J" first="J.-C." last="Corvol">J.-C. Corvol</name>
<name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V." last="Czernecki">V. Czernecki</name>
<name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V." last="Czernecki">V. Czernecki</name>
<name sortKey="Czernecki, V" sort="Czernecki, V" uniqKey="Czernecki V" first="V." last="Czernecki">V. Czernecki</name>
<name sortKey="Djebara, M B" sort="Djebara, M B" uniqKey="Djebara M" first="M. B." last="Djebara">M. B. Djebara</name>
<name sortKey="Djebara, M B" sort="Djebara, M B" uniqKey="Djebara M" first="M. B." last="Djebara">M. B. Djebara</name>
<name sortKey="Djebara, M B" sort="Djebara, M B" uniqKey="Djebara M" first="M. B." last="Djebara">M. B. Djebara</name>
<name sortKey="Djebara, M B" sort="Djebara, M B" uniqKey="Djebara M" first="M. B." last="Djebara">M. B. Djebara</name>
<name sortKey="Golmard, J L" sort="Golmard, J L" uniqKey="Golmard J" first="J.-L." last="Golmard">J.-L. Golmard</name>
<name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A." last="Hartmann">A. Hartmann</name>
<name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A." last="Hartmann">A. Hartmann</name>
<name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A." last="Hartmann">A. Hartmann</name>
<name sortKey="Hartmann, A" sort="Hartmann, A" uniqKey="Hartmann A" first="A." last="Hartmann">A. Hartmann</name>
<name sortKey="Schupbach, W M M" sort="Schupbach, W M M" uniqKey="Schupbach W" first="W. M. M." last="Schüpbach">W. M. M. Schüpbach</name>
<name sortKey="Schupbach, W M M" sort="Schupbach, W M M" uniqKey="Schupbach W" first="W. M. M." last="Schüpbach">W. M. M. Schüpbach</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Schupbach, W M M" sort="Schupbach, W M M" uniqKey="Schupbach W" first="W. M. M." last="Schüpbach">W. M. M. Schüpbach</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Segmental progression of early untreated Parkinson's disease: a novel approach to clinical rating

Segmental progression of early untreated Parkinson's disease: a novel approach to clinical rating

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